Ananth Annapragada |
The Systems Biology Grand Challenge: Personalized Medicine With the advent of languages and packages well suited for the annotation and simulation of cellular biological pathways ( e.g. SBML, VirtualCell, GEPASI) a tantalizing picture of the clinical applications of Systems Biology is emerging. The long sought-after goal of Personalized Medicine is a significant portion of this picture. In this talk, I will present 3 examples from my laboratory, at the Cell level, at the Organ level and at the Organism level, where detailed simulations have played, and can continue to play, huge roles in the development of therapies. Conventional deterministic models, monte-carlo models and logical models will be discussed in the context of predictive, personalized medicine. |
