All Day Workshops |
WS1 |
Synthetic Biology |
WS2 |
CANCELLED |
WS3 |
Exploring 3D Molecular Structures Using NCBI Tools |
WS4 |
Comparative Genome Analyses of Bacterial Genomes and Applications |
WS5 |
Symbolic Systems Biology |
WS6 |
CANCELLED |
WS7 |
Bioinformatics Curriculum Development Workshop (see special notes) |
WS1
Synthetic Biology
This workshop will cover the design and construction of biological
systems that exhibit complex dynamical or logical behavior. As such it will appeal to a diverse audience
including those working in biological engineering, biochemistry, quantitative biology, biophysics, molecular
and cellular biology, bioethics, policy and governance, and biotechnology. The workshop's organization
will introduce researchers to the emerging and rapidly developing field of synthetic biology.
Areas of particular emphasis include:
- The general direction of the field
- Exciting and innovative research directions
- Challenges currently faced by research
- Breakthroughs needed to overcome the challenges
Organizer and Speaker
- Christina Smolke
Assistant Professor of Chemical Engineering, California Institute of Technology
http://cheme.che.caltech.edu/groups/cds/
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WS3
Exploring 3D Molecular Structures Using NCBI Tools
The National Center for Biotechnology Information
(NCBI) presents a
workshop that includes lectures and training that teach the effective
use of NCBI databases, search services, and analysis tools that focus
on 3D macromolecular structure data.
After attending the workshop, participants should be able to do the
following:
- Understand the origin and organization of 3D structural data and
how these data are curated at NCBI
- Find structural neighbors using VAST and functional elements
within structures using the Conserved Domain Database and
RPS-BLAST
- Analyze a 3D structure, highlight features such as bound ligands
and active site residues, create customized annotations, and save
and export a figure
- Find and evaluate a 3D modeling template for a protein by creating
multiple sequence alignments using either sequence or similarity
searches
The workshop is intended for principal investigators, postdoctoral
fellows, graduate students, advanced undergraduates, and other
scientific staff who either work with 3D structural data or are
interested in understanding how to incorporate such data into their
research. No prior experience with structural data is
required. Familiarity with basic computer operation and common Web
browsers is assumed.
More detailed information about the workshop can be found at:
http://www.ncbi.nlm.nih.gov/Class/Structure/course.html
Organizer and Speaker
- Eric W. Sayers
National Center for Biotechnology Information
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WS4
Comparative Genome Analyses of Bacterial Genomes and Applications
The world-wide genome sequencing efforts have produced roughly 400
complete bacterial genomes, and this number is expected to extend
beyond 10,000 within the next few years. As the pool of complete
bacterial genomes rapidly grows, comparative genomic analysis surfaces
as one of the most important classes of tools both for mining the
genomes and for studying bacterial biology and evolution at a systems
level. The community urgently needs more powerful methodologies,
tools, and application protocols to help address fundamental
biological problems related to the mechanisms of bacterial genome
evolution and associated areas of research.
Invited scientists from leading research centers and laboratories will
present their work in the field of comparative genomic analysis,
particularly for the study of bacterial biology and evolution, which
may cover but may not be limited to the following topics:
- Modeling phylogenetic and environmental diversities of bacterial
genomes and its application to the design of comparative genomic
analysis
- Prediction and analysis of homologous/orthologous genes with the
presence of uncertainty and noise
- Prediction and analysis of cis-regulatory elements and their
homologs/orthologs across bacterial genomes
- Prediction and analysis of high-level genomic structures (e.g.,
operons, uber-operons, and regulons) and their homologs/orthologs
across different bacterial genomes
- Prediction and analysis of biological networks/pathways and their
homologs/orthologs across different bacterial genomes
- Evolution and adaptation of bacterial genomes
- Metagenomics
- Computational issues
The workshop is aimed at eliminating barriers and providing a platform
for researchers from different disciplines to exchange visions,
insights, ideas, and discoveries about the challenges and
opportunities in the field, to share and appreciate research efforts
that have been devoted to the field, to provide and seek
advice/suggestion/solutions to some problems in the field, and to
establish face-to-face collaboration.
Speakers
- Robert Edwards
Fellowship for Interpretation of Genomes, and
San Diego State University
- Jonathan A. Eisen
The Institute for Genomic Research
- Arthur Grossman and Devaki Bhaya
Stanford University
- Kostas Mavrommatis
Joint Genome Institute
- Maria Poptsova
University of Connecticut
- Heidi Sofia
Pacific Northwest National Lab
- John C. Wooley
University of California at San Diego
- Ying Xu
University of Georgia
Organizers
- John C. Wooley
University of California at San Diego
- Hongwi Wu and Fenglou Mao
Computational Systems Biology Lab
Department of Biochemistry and Molecular Biology
University of Georgia
- Heidi Sofia
Computational Biology and Bioinformatics
Pacific Northwest National Lab
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WS5
Symbolic Systems Biology
Symbolic systems biology is the qualitative and quantitative study of biological processes and integrated systems rather than isolated parts. In addition to traditional models based on differential equations or statistical/probabilistic methods, formal logics and formal methods techniques are applied to modeling and analysis of biological systems. Abstraction techniques and formal logic are well suited to relate and integrate quantitative mathematical and qualitative algebraic/logical models.
This workshop will bring together biologists, computer scientists, and mathematicians to exchange ideas and discuss new logical and mathematical techniques for biological modeling and analysis. In particular, the workshop emphasizes techniques that increase our understanding of biological processes such as metabolism, signal transduction, gene regulation, inter-cellular communication (immune system, neurons, ...).
Expected benefits for participants:
- plans for new synergistic collaborations
- increased understanding of questions biologists want to ask of models
- increased understanding of modeling capabilities and meaningful ways to compose multiple models
The workshop program will include presentations from two keynote speakers,
short presentations of selected position papers, and group discussions focused
on possible new directions and challenge problems.
Keynote speakers
Professor Vito Quaranta---Integrative Mathematical Model of Cancer Invasion (abstract)
Professor Ananth Annapragada---The Systems Biology Grand Challenge: Personalized Medicine (abstract)
Vito Quaranta is professor of cancer biology at Vanderbilt University,
director of the Vanderbilt Integratice Cancer Biology Center
and co Director of the Vanderbilt Center for Matrix Biology.
(http://www.mc.vanderbilt.edu/cmb/indiv_member.php?id=2)
Ananth Annapragada (http://www.sahs.uth.tmc.edu/AANNAPRAGADA/)
is a member of the faculty of the School of Health Information
Sciences at U. Texas-Houston. His research interests includer targeted drug
delivery; respiratory drug delivery; computational methods in biomedicine; and
targeted delivery of contrast agents for various imaging modalities.
Prospective participants are encouraged to send a 1-4 page position paper
(ascii text or pdf preferred) discussing ideas and issues related to the
workshop topic to Andy Poggio (poggio@csl.sri.com) by July 21, 2006.
The workshop is sponsered by the SRI Center for Computational Biology
(http://ccb.csl.sri.com/).
Organizer: Carolyn Talcott
Co-Organizer: Andy Poggio
Center for Computational Biology
SRI International
333 Ravenswood Avenue
Menlo Park, CA 94025
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WS7
Bioinformatics Curriculum Development Workshop
The rapid increase in interest in bioinformatics has created great pressure on faculty to offer courses at both the introductory and advanced levels. These teaching opportunities are difficult to meet because there are still only a few faculty members in bioinformatics. The mission of the effort (originated at this workshop) is to bring together faculty with active teaching missions to share curricular philosophy as well as detailed course materials, syllabi and lectures. By bringing together those who teach bioinformatics at the introductory graduate (or advanced undergraduate) level, the goal of the initial workshop is to assess the teaching resources that are available, outline and assess extant curriculum, and make teaching materials available to others
The format of the meeting will include 1-2 plenary presentations and if the group is large, breakout groups on individual topics in the curriculum (e.g. sequence analysis, structure analysis, functional analysis, simulation). The groups will return with a plan for sharing of course materials, and recommendations on the focus on followup workshops.
Special Notes:
Attendance: By invitation, preference given to those who have taught courses in bio/biomedical informatics, and are in a position to share materials. If you wish to attend please contact bioinfws@olympus.compbio.iupui.edu. You should provide a CV, a synopsis of your teaching experience and a course description plus outline.
Fees: There are no fees to attend this workshop. Lunch will not be provided; we will adjourn to nearby eateries on campus.
Speakers
Russ Altman, Stanford University
Organizers
- John Wooley
- Sean Mooney
- Olga Troyanskaya
- Betty Cheng
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